Abstract: A moisture curable adhesive composition includes an isocyanate-terminated polyurethane prepolymer that is a reaction product of a polyol component and an isocyanate component. The polyol component includes a polylactide polyol that is a reaction product of a lactide and a hydroxyl-functional initiator selected from the group consisting of glycerol, a fatty acid monoglyceride, a fatty acid diglyceride, and combinations thereof.